Targeting the Alk4 pathway protects against age-related bone loss.
David E. Maridas, Shek Man Chim, Kathryn M. Burton, Emily Van Doren, Laura Gamer, Kyle Kirshen, Eren Keles, Karla Avalos, Radhika S. Kethani, Vicki Rosen
This study shows inhibiting the Alk4 pathway in aging mice prevents age-related bone loss and sarcopenia by reducing Activin signaling.
bioRxiv · Oct 24, 2025 · PreprintCell Biology