A generative framework for enhanced cell-type specificity in rationally designed mRNAs
Matvei Khoroshkin, Arsenii O. Zinkevich, Elizaveta Aristova, Hassan Yousefi, Sean Bong Lee, Tabea Mittmann, Karoline Manegold, Dmitry Penzar, David Ronan Raleigh, Ivan V. Kulakovskiy, Hani Goodarzi
This paper introduces PARADE, a generative AI framework for designing mRNA UTRs with cell-type specificity, showing improved therapeutic efficacy in preclinical models.
bioRxiv · Dec 31, 2024 · PreprintSystems Biology