Sean Bong Lee

This study identifies DSRCT-specific neogenes regulated by the EWS::WT1 fusion protein and shows their potential as biomarkers and therapeutic targets in desmoplastic small round cell tumors.

The paper identifies ZZEF1 as a tRNA-specific transcription factor that suppresses breast cancer metastasis by regulating tRNA-LysUUU expression and affecting codon-specific translation.

This paper introduces PARADE, a generative AI framework for designing mRNA UTRs with cell-type specificity, showing improved therapeutic efficacy in preclinical models.

The paper systematically identifies post-transcriptional regulatory modules by integrating multimodal data on RBP interactions and functions.

The paper shows enzalutamide reduces DSRCT growth independently of AR, challenging the hypothesis that AR drives male predominance in this cancer.