Systems BiologybioRxivPreprint
A generative framework for enhanced cell-type specificity in rationally designed mRNAs
Matvei Khoroshkin, Arsenii O. Zinkevich, Elizaveta Aristova…·Hani Goodarzi
This paper introduces PARADE, a generative AI framework for designing mRNA UTRs with cell-type specificity, showing improved therapeutic efficacy in preclinical models.