2'-O-Methylated ncRNA condensates form a recombination center for IgH synapsis
Maki Kobayashi, Jianliang Xu, Afzal Husain, Takahito Moriwaki, Ziwei Yin, Xi Chen, Wencong Wang, Toshitsugu Fujita, Hodaka Fujii, Luthfi Lulul Ulum, Takanori Oyoshi, Kanon Omura, Kei Iida, Hidetaka Kosako, Tasuku Honjo
This study shows that FBL-mediated 2'-O-methylation of GLTs forms condensates that drive IgH synapsis and CSR in B cells.
bioRxiv · Nov 6, 2026 · PreprintMolecular Biology