Human NLRC4 can act as a direct sensor for cytosolic flagellin
Gaopeng Li, Kenyatta Doumanas, Xiao Liu, Nadya Panagides, Liudmila Andreeva, Florian Ingo Schmidt, Clare Elizabeth Bryant, Alexander N.R. Weber
This study shows human NLRC4 can directly sense cytosolic flagellin without NAIP, while NAIP may inhibit this response.
bioRxiv · Oct 8, 2026 · PreprintImmunology