Clare Elizabeth Bryant

This study shows human NLRC4 can directly sense cytosolic flagellin without NAIP, while NAIP may inhibit this response.

The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.

The paper identifies hexa-acylated lipopolysaccharides from the gut microbiome as a biomarker and enhancer of anti-PD-1 immunotherapy responses in melanoma patients.

This study shows that an inherited mtDNA mutation alters inflammatory cytokine responses in macrophages and in vivo, leading to increased IFN-I and reduced pro-inflammatory cytokines.

This study shows that DNA-PK is a conserved DNA sensor in chickens that poxviruses evade by targeting with OPG020/OPG031 proteins, highlighting its role in innate immunity beyond mammals.

This paper models the innate immune responses of chickens and ducks to HPAIV, identifying RIG-I as a key molecular difference affecting immune outcomes.

This study evaluates the male ovine mammary gland microenvironment, comparing intact and neutered males, and demonstrates its utility as a model for male breast biology.

This study shows that Aβ aggregates trigger TLR4 less efficiently than LPS due to slower Myddosome formation and longer lifetimes of larger Myddosomes.

This paper introduces an automated optical electrowetting-on-dielectric platform for performing complex single-cell assays in parallel, enabling direct functional analysis of individual cells.

This study investigates how chicken TLR21 triggers type I interferon production in macrophages, revealing conserved signaling pathways with mammalian TLR9.

The paper shows that Salmonella uses the SPI-1 injectisome to trigger rapid translation of transcription factors in macrophages, which suppresses inflammation and cell death to aid infection.

TRIAGE integrates pathway and network methods to optimize gene hit selection from high-throughput assays, improving consistency across genome-wide studies.

The paper examines soluble Aβ aggregates in CSF from AD, MCI, and healthy controls, finding stage-specific differences in aggregate size and toxicity mechanisms.