Transient Splicing-Associated Isoform Remodeling Defines Early MAPKi Resistance Adaptation in Melanoma
Sumit Mukherjee, Arashdeep Singh, Sumeet Patiyal, Hyunjeong Joo, Hyungsoo Kim, Lipika R. Pal, Kun Wang, Chi‐Ping Day, Ze’ev A. Ronai, Eytan Ruppin, Sridhar S. Hannenhalli
The paper identifies transient isoform remodeling as a key mechanism in early MAPKi resistance in melanoma, showing it is distinct from gene expression changes and linked to splicing regulators and developmental pathways.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology