Han Zhou

A conservative moving-boundary multiphysics framework reveals nonlinear coupling between osmotic flow and actin-driven cell migration

This paper develops a multiphysics framework to model cell migration by coupling osmotic flow with actin dynamics, showing how cytosolic convection influences migration through nonlinear interactions.

Objective curriculum-guided design of multi-property proteins

This paper introduces OCDesign, a curriculum-guided framework for multi-property protein design, showing that staged objective introduction improves success rates compared to one-shot optimization.

Exploration of the screening and regulatory mechanisms of biomarkers related to ac4C modification in laryngeal squamous cell carcinoma patients based on single-cell analysis and machine learning

The paper identifies seven ac4C-related prognostic genes in laryngeal squamous cell carcinoma using single-cell analysis and machine learning, showing their association with immune microenvironment alterations.

Host EV derived lipids promote malaria parasite development via mosquito fatty acid oxidation

The paper shows that host-derived extracellular vesicles promote malaria parasite development in mosquitoes by reprogramming lipid metabolism through fatty acid oxidation.

Targeted Protein Degradation by KLHDC2 Ligands Identified by High Throughput Screening

This paper identifies a novel small molecule scaffold targeting KLHDC2 via high throughput screening and demonstrates its utility in degrading BRD4 using PROTACs.

Natural Selection in a Synthetic Yeast Endosymbiont Promotes Stable Coexistence

The paper shows that natural selection in a synthetic yeast endosymbiont system leads to mutations that enhance bacterial coexistence within yeast.