Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer
Claudia Manriquez Roman, Elizabeth L. Siegler, Justyna Trynda, Truc N Huynh, Grace E. DeFranco, Aylin Alasonyalılar Demirer, Matthew L. Pawlush, Michael Redig, Skyeler M. Klinge, Long K. Mai, James L. Miller, Erin E. Miller, Brooke L. Kimball, Erin E. Tapper, Reona Leo Sakemura, , Saad S. Kenderian
This paper develops a TSHR-targeted CART cell therapy for thyroid cancer and shows that combining it with MAPK inhibitors improves antitumor efficacy in dedifferentiated thyroid cancers.
bioRxiv · Mar 15, 2024 · PreprintImmunology