Author

Saad S. Kenderian

Mayo ClinicORCID 0000-0003-2767-3830Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Brooke L. KimballiD· 2 shared Carli M. StewartiD· 2 shared Elizabeth L. SiegleriD· 2 shared Reona Leo SakemuraiD· 2 shared Abba Zubair· 1 shared Alexandre Gaspar‐MaiaiD· 1 shared Aylin Alasonyalılar DemireriD· 1 shared Claudia Manriquez RomaniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

Brooke L. KimballORCID

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2 papers

Recent·Most cited

ImmunologyNature CommunicationsPeer-reviewedSep 12, 2024

The Identification of IL-4 as a Regulator of Chimeric Antigen Receptor T Cell Exhaustion

Carli M. Stewart, Elizabeth L. Siegler, Reona Leo Sakemura…·Saad S. Kenderian

This study identifies IL-4 as a regulator of CART cell exhaustion and shows that IL-4 neutralization improves antitumor efficacy.

50 citationstop 1%

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ImmunologybioRxivPreprintMar 15, 2024

Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer

Claudia Manriquez Roman, Elizabeth L. Siegler, Justyna Trynda…·Saad S. Kenderian

This paper develops a TSHR-targeted CART cell therapy for thyroid cancer and shows that combining it with MAPK inhibitors improves antitumor efficacy in dedifferentiated thyroid cancers.

1 citation

humanexperimental assay

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