Author

Brooke L. Kimball

Mayo ClinicORCID 0009-0009-3308-2704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Carli M. StewartiD· 3 shared Elizabeth L. SiegleriD· 3 shared Reona Leo SakemuraiD· 2 shared Saad S. KenderianiD· 2 shared Abba Zubair· 1 shared Adam J. DupuyiD· 1 shared Adam L. BurrackiD· 1 shared Alex T. LarssoniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersImmunology

Carli M. StewartORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologyJournal for ImmunoTherapy of CancerPeer-reviewedJul 1, 2026

Sleeping Beauty mutagenesis identifies BACH2 and other regulators of CD8+T cell exhaustion, persistence in vivo, and CAR-T function under tumor-associated chronic antigen stimulation

Chang-Jung Lee, Alex T. Larsson, Tyler A. Jubenville…·David A. Largaespada

The paper uses Sleeping Beauty mutagenesis to identify BACH2 and other genes that enhance CD8+ T cell persistence and function under chronic antigen stimulation, improving engineered T cell therapies.

1 citation

mousescRNA-seq

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ImmunologyNature CommunicationsPeer-reviewedSep 12, 2024

The Identification of IL-4 as a Regulator of Chimeric Antigen Receptor T Cell Exhaustion

Carli M. Stewart, Elizabeth L. Siegler, Reona Leo Sakemura…·Saad S. Kenderian

This study identifies IL-4 as a regulator of CART cell exhaustion and shows that IL-4 neutralization improves antitumor efficacy.

50 citationstop 1%

humanscRNA-seq

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ImmunologybioRxivPreprintMar 15, 2024

Optimized CART Cell Therapy for Metastatic Aggressive Thyroid Cancer

Claudia Manriquez Roman, Elizabeth L. Siegler, Justyna Trynda…·Saad S. Kenderian

This paper develops a TSHR-targeted CART cell therapy for thyroid cancer and shows that combining it with MAPK inhibitors improves antitumor efficacy in dedifferentiated thyroid cancers.

1 citation

humanexperimental assay

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