BIRC5 dependency defines a targetable vulnerability in TP53 mutant acute myeloid leukemia
Ahmed M. Mamdouh, Fang Qi Lim, Yang Mi, Elyse A. Olesinski, Shaista Shabbir Jasdanwala, Xiao Xian Lin, Edward Ayoub, Jordan Yong Ming Tan, Karanpreet Singh Bhatia, Yichen Wang, Shradha Garnaik, Kunal Tomar, Valeriia Sapozhnikova, Cheryl Gek Teng Chan, Chuqi Wang, , Shruti Bhatt
This study identifies BIRC5 as a targetable vulnerability in TP53 mutant AML, showing that survivin/IAP inhibitors can overcome therapy resistance.
bioRxiv · May 17, 2025 · PreprintCancer Biology