ICOS blockade alleviates immune suppression in breast tumor microenvironment
Shalini Guleria, Chamikara Liyanage, William J. Hutchison, Kurtis Treller, Liam Neil, Yingnan Gao, Belinda Jane Yeo, John Martin Mariadason, Conor J. Kearney, Lisa Anna Mielke, Axel Kallies, Sadanand Vodala, Robin L. Anderson, Delphine Mérino, Anthony T. Papenfuss, , Bhupinder Pal
This study shows that blocking ICOS reduces immune suppression in breast tumors by altering Treg and CD8 T cell dynamics, enhancing anti-tumor immunity.
bioRxiv · Oct 23, 2026 · PreprintCancer Biology