Lisa Anna Mielke

This study shows that blocking ICOS reduces immune suppression in breast tumors by altering Treg and CD8 T cell dynamics, enhancing anti-tumor immunity.

This study identifies Menin's MLL-independent role in promoting resistance to MAPK-targeted therapy in BRAF-mutant colorectal cancer.

This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.

This study identifies immune cell signatures in peripheral blood that correlate with metastatic burden in breast cancer patients using single-cell transcriptomics.