William A. Weiss

The paper identifies six distinct tumor microenvironment niches in glioblastoma that correlate with patient survival and immunotherapy response.

NOVA is an R-package for analyzing MEA data, offering dimensionality reduction, clustering, and trajectory mapping, revealing network burst duration as a key activity metric.

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

This study uses in vivo perturb-seq to analyze gene function and radiotherapy responses in glioblastoma by targeting cancer and microenvironment cells.

This study shows PRDM6 represses chromatin accessibility and alters gene expression in neuroepithelial stem cells, promoting medulloblastoma but not sufficient to drive Group 4 medulloblastoma alone.