The expression of congenital Shoc2 variants induces AKT-dependent feedback activation of the ERK1/2 pathway
P. Wilson, L. Abdelmoti, T. Gao, E. Galperin
This study shows that Shoc2 variants associated with NSLH alter ERK1/2 phosphorylation levels depending on AKT pathway activation, revealing a feedback mechanism in EGFR signaling.
bioRxiv · Dec 23, 2023 · PreprintBiochemistry