T. Gao

Microglia Piezo1 aggravates cerebral ischemia and reperfusion injury by chemotactic recruitment of T lymphocytes

This study shows that microglia Piezo1 deficiency reduces T lymphocyte infiltration and inflammation after cerebral ischemia reperfusion injury.

Dysregulation of mitochondrial function by PLK1-mediated PDHA1 phosphorylation promotes Cr(VI)-associated lung cancer progression

This study shows that PLK1-mediated PDHA1 phosphorylation impairs mitochondrial function and promotes Cr(VI)-induced lung cancer progression by disrupting energy metabolism and apoptosis.

The expression of congenital Shoc2 variants induces AKT-dependent feedback activation of the ERK1/2 pathway

This study shows that Shoc2 variants associated with NSLH alter ERK1/2 phosphorylation levels depending on AKT pathway activation, revealing a feedback mechanism in EGFR signaling.

Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

This study identifies cross-reactive intrahepatic antibodies in severe alcoholic hepatitis that target both bacterial antigens and human proteins, suggesting a role in disease pathogenesis.

Structure of a G protein-coupled receptor with GRK2 and a biased ligand

The paper reports the structure of NTSR1 bound to GRK2, Gq, and a biased ligand, revealing how the ligand enhances GRK2 binding and enables arrestin-biased signaling.

Inhibition of Talin-induced Integrin Activation by a Double-hit Stapled Peptide

This study develops a stapled peptide inhibitor that blocks talin-induced integrin activation by targeting both talin head and rod domains.

A non-destructive approach for measuring rice panicle-level photosynthetic responses using 3D-image reconstruction

This paper develops a non-destructive method to measure rice panicle-level photosynthetic responses using 3D imaging and gas exchange analysis, revealing differential responses to heat stress between two rice genotypes.

Effects of seasonal changes on the carbon dynamics in mixed coniferous forests

This study examines seasonal changes in litter and soil carbon dynamics in mixed coniferous forests through freeze-thaw experiments, revealing how temperature fluctuations affect carbon release and mass loss.

Direct RNA sequencing of Respiratory Syncytial Virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance

This study uses direct RNA sequencing to analyze RSV mRNA transcripts in infected cells, revealing gene abundance patterns and polyadenylate tail lengths.

Effect of Aeromonas hydrophila infected on metabolomic response and gut microbial 16S rRna of Charybdis japonica

This study investigates how Aeromonas hydrophila infection affects the metabolomic response and gut microbiota of Charybdis japonica, showing that certain bacteria and metabolites help resist infection.

SARS-CoV-2 receptor ACE2 identifies immuno-hot tumors in breast cancer

This study identifies ACE2 as a marker of immuno-hot tumors in breast cancer by analyzing its expression and correlation with immune features across multiple datasets.

Evaluation of different concentrations antibiotics on gut bacteria and growth of Ectropis obliquaProut (Lepidoptera: Geometridae)

This study evaluates antibiotic concentrations affecting gut bacteria and Ectropis obliqua growth, finding 300g/ml effectively clears bacteria without harming growth.

Wild emmer introgressions alter root-to-shoot growth dynamics in response to water stress

The paper examines how wild emmer introgressions affect root-to-shoot growth dynamics under water stress in wheat, identifying a line with high plasticity and candidate genes for stress adaptation.

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity

This study shows that sorcin enhances ATF6 transcriptional activity, which is reduced during lipotoxic stress and contributes to beta cell failure in type 2 diabetes.

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron

This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.

Optimum Threshold Minimizes Noise in Timing of Intracellular Events

The paper studies how noise in holin expression affects lysis timing in E. coli infected by bacteriophage λ, finding that noise decreases to a minimum and then increases with lysis time.

PI-Plat: A high-resolution image-based 3D reconstruction method to estimate growth dynamics of rice inflorescence traits

The paper introduces PI-Plat, a 3D imaging method to estimate rice inflorescence growth dynamics, showing voxel count correlates with seed number and maturation rate.

An Inflammatory Clock Predicts Multi-morbidity, Immunosenescence and Cardiovascular Aging in Humans

The paper develops an inflammatory clock of aging (iAge) using blood immunome data from 1001 individuals, showing it correlates with multi-morbidity, immunosenescence, and cardiovascular aging.

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

Assessment of the World Largest Afforestation Program: Success, Failure, and Future Directions

The paper assesses the Three-North Afforestation Program's first 30 years, finding increased forest area but declining quality, limited desertification reduction, and low shelterbelt coverage.