Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironment
L. Anandi, J. Garcia, M. Ros, L. Janska, J. Liu, C. Carmona-Fontaine
The paper introduces an ex vivo model called 3MIC to study metastatic features in tumor cells under various metabolic conditions and stromal interactions, finding that extracellular acidification is more critical than hypoxia in promoting metastasis.
bioRxiv · Jan 9, 2023 · PreprintCancer Biology