J. Garcia

PCM1 conveys centrosome asymmetry to polarized endosome dynamics in regulating daughter cell fate

This study shows that Pcm1 regulates asymmetric endosome dynamics and RGP fate by coordinating Rab5b and Rab11a endosome markers and Par-3/dynein complexes in zebrafish and human brain organoids.

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi

The paper uses weighted whole-genome methylation analysis to distinguish between congenital and acquired melanocytic nevi.

Conformational switching of Arp5 subunit differentially regulates INO80 chromatin remodeling

This study identifies two distinct binding mechanisms of the Arp5 subunit in the INO80 chromatin remodeler, showing their differential roles in nucleosome positioning and dimer exchange.

Seasonal behavioral patterns of the Caqueta titi monkey (Plecturocebus caquetensis)

This study describes the seasonal behavioral patterns and home range of the Critically Endangered Caqueta titi monkey in Colombia, identifying a priority conservation area.

Perpetual bioplastic production by a cyanobacteria-dominated microbiome

This study demonstrates continuous PHB production by a cyanobacteria-dominated microbiome in a non-sterile photobioreactor, achieving 28% dry cell weight over 108 days.

Antidiabetic Drugs May Prevent Kidney Damage

This study shows canagliflozin prevents kidney damage from ischemia and reperfusion in non-diabetic rats by improving renal function and reducing oxidative stress.

New strategy for bioplastic and exopolysaccharides production: Enrichment of field microbiomes with cyanobacteria

The paper tests field microbiomes enriched with cyanobacteria for PHB and EPS production under different culture conditions, finding optimal parameters for biopolymer synthesis.

Species composition determines bioplastics production in photosynthetic microbiomes: strategy to enrich cyanobacteria PHB-producers

This study identifies nutrient, temperature, and light strategies to enrich a cyanobacteria-rich microbiome for enhanced PHB production, achieving up to 22% dry cell weight.

Kinetic stabilization of translation-repression condensates by a neuron-specific microexon

The paper shows that a neuron-specific microexon in CPEB4 stabilizes translation-repression condensates by competing with aggregation, enabling reversible regulation of gene expression in neurons.

Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironment

The paper introduces an ex vivo model called 3MIC to study metastatic features in tumor cells under various metabolic conditions and stromal interactions, finding that extracellular acidification is more critical than hypoxia in promoting metastasis.

Rational optimization of a transcription factor activation domain inhibitor

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

A glutamine-based single α-helix scaffold to target globular proteins

This paper introduces a method to design peptides that fold into single α-helices using glutamine side chain to main chain hydrogen bonds, enabling targeted interactions with globular proteins.

Regulation of prostate androgens by megalin and 25-hydroxyvitamin D status: Mechanism for high prostate androgen in African American men

This study shows megalin regulates prostate androgen levels by importing testosterone bound to sex hormone-binding globulin, and 25-hydroxyvitamin D suppresses megalin, linking vitamin D deficiency to higher prostate androgens in African American men.

Pooled screening of CAR T cells identifies non-native signaling domains for next- generation immunotherapies

This study identifies non-native signaling domains in CAR T cells that enhance proliferation or cytotoxicity, offering improved designs for immunotherapies.

Quantifying the dynamics of viral recombination during free virus and cell-to-cell transmission in HIV-1 infection

This study quantifies how HIV-1 recombination dynamics differ between free virus and cell-to-cell transmission, finding faster recombination with cell-to-cell transmission due to increased infection multiplicity and co-transmission of viral strains.

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

Distinct Long-term Effects of Precision X-Radiation on Reflex Saliva Flow Rate and Tissue Integrity in a Preclinical Model of Chronic Hyposalivation

This study develops a novel preclinical model to assess long-term effects of precision radiation on salivary function and tissue integrity in mice.

A negative feedback loop mediated by the NR4A family of nuclear hormone receptors restrains expansion of B cells that receive signal one in the absence of signal two

This study identifies a negative feedback loop involving NR4A receptors that limits B cell proliferation without T cell help and enhances antibody responses to T-independent antigens.

Auditory Countermeasures for Sleep Inertia: An Ecological Study Examining the Influence of Melody and Rhythm.

This study examines how melodic and rhythmic auditory stimuli affect sleep inertia, finding that melodies significantly reduce attentional lapses and improve performance scores compared to control and rhythmic conditions.

In vivo characterisation of the toxicological properties of DPhP, one of the main degradation products of aryl phosphate esters.

This study investigates the toxicological effects of DPhP in mice, finding significant biological impacts including altered fatty acid metabolism and weight loss.

GHSR-1a is not Required for Ghrelin's Anti-inflammatory and Fat-sparing Effects in Cancer Cachexia

This study shows ghrelin prevents white adipose tissue inflammation and atrophy in cancer cachexia, but GHSR-1a is only needed for its appetite-stimulating effect.

Monodelphis domestica as a fetal intra-cerebral inoculation model for Zika virus pathogenesis

This paper demonstrates that Monodelphis domestica is a suitable model for studying Zika virus pathogenesis in fetal brains, showing persistent infection and neural pathology.

In Depth Flow Inspection Using Dynamic Laser Speckle Temporal Statistics

The paper introduces an optical method using dynamic laser speckle temporal statistics to analyze tissue flow, distinguishing Brownian motion from laminar flow with in-vivo and in-vitro results.

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor

This study investigates how polyglutamine tract length affects the structure and function of the androgen receptor, revealing hydrogen bonds that stabilize a helical conformation linked to transcriptional activity and disease.

A computational model of task allocation in social insects: ecology and interactions alone can drive specialisation

This paper develops a computational model showing that ecology and social interactions alone can drive task specialization in social insect colonies, with weak specialization being more adaptive in dynamic environments.