Mechanosensing through direct binding of tensed F-actin by LIM domains
X. Sun, D. Y. Z. Phua, L. Axiotakis, M. A. Smith, E. Blankman, R. Gong, R. C. Cail, S. Espinosa de los Reyes, M. C. Beckerle, C. M. Waterman, G. M. Alushin
The paper identifies LIM domains' direct binding to tensed F-actin as a mechanosensing mechanism, showing force-dependent sequestration affects nuclear localization.
bioRxiv · Mar 6, 2020Biophysics