X. Sun

Spatio-temporal mapping of immune cell dynamics during human sequential lymph node metastasis

This study maps immune cell dynamics during human sequential lymph node metastasis using multi-omics approaches and identifies immune alterations linked to patient survival.

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

The Plasmodiophora brassicae effector PbEGF1 manipulates plant immunity and regulate primary infection

This study identifies PbEGF1, an effector from Plasmodiophora brassicae, which manipulates plant immunity and promotes infection by degrading BnNHL13.

I2Bot: an open-source tool for multi-modal and embodied simulation of insect navigation

I2Bot simulates insect navigation by integrating morphology, sensory capabilities, and environment, revealing navigation principles for robotics.

Interspecies interaction reshapes the fitness landscape of evolved genotypes

This study investigates how interspecies interactions shape genetic and phenotypic diversity in a two-species microbial consortium over evolutionary time.

PFS alleviates bone destruction in collagen-induced arthritis mice associated with macrophage polarization

This study shows that PFS reduces bone destruction and shifts macrophage polarization from M1 to M2 in arthritis mice, suggesting its potential as an RA treatment.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

Bridging the Gap: biofilm-mediated establishment of Bacillus velezensis on Trichoderma guizhouense mycelia

This study investigates bacterial-fungal interactions between Bacillus velezensis and Trichoderma guizhouense, showing biofilm-mediated colonization and gene expression changes that reveal complex dynamics in soil microbiota.

Protective Effect of 2-Hydroxyestrone and2-Hydroxyestradiol Against Chemically-Induced Hepatotoxicity In Vitro and In Vivo

This study shows that 2-hydroxyestrone and 2-hydroxyestradiol protect against ferroptosis in hepatoma cells and acetaminophen-induced liver injury by inhibiting PDI activity and reducing NO, ROS, and lipid-ROS accumulation.

Force-activated zyxin assemblies coordinate actin nucleation and crosslinking to orchestrate stress fiber repair

This study reveals how zyxin assemblies coordinate actin nucleation and crosslinking to repair stress fibers in response to mechanical forces.

A Membrane Lipid Signature Unravels the Dynamic Landscape of Group 1 ILCs

This study uses the AsGM1 membrane lipid signature to distinguish NK cells and ILC1s, capturing their plasticity across tissues and conditions.

Regulation of lung cancer initiation and progression by the stem cell determinant Musashi

This study identifies Msi2 as a key regulator in lung cancer initiation and progression, showing its dual role in sensitizing cells to transformation and driving tumor growth.

Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi

The paper challenges the classical cisternal progression model by showing that intra-Golgi transport velocity varies and Golgi residence times differ for different cargos, suggesting a stable compartment model.

No Reliable Evidence Supports the Presence of Javan Tigers - Data Issues Related to the DNA Analysis of a Recent Hair Sample

The paper reanalyzes mtDNA data from a claimed Javan tiger hair sample and finds the sequences likely represent nuclear mitochondrial DNA with high mismatches, indicating unreliable data.

Sex-Specific Cardiovascular Adaptations to Simulated Microgravity in Sprague-Dawley Rats

This study examines sex-specific cardiovascular adaptations to simulated microgravity in rats, finding increased arterial stiffness in females but not males.

Mutation of negative regulatory gene CEHC1 encoding an FBXO3 protein results in normoxic expression of HYDA genes in Chlamydomonas reinhardtii

The paper identifies a mutation in CEHC1, which encodes FBXO3, leading to normoxic expression of HYDA genes in Chlamydomonas reinhardtii by stabilizing CRR1.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

A perivascular niche supports endometrial epithelial regeneration

This study identifies Nestin+ perivascular cells as contributors to endometrial epithelial regeneration through estrogen-stimulated suppression of Notch signaling.

Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study of the free enzyme and its complex with inhibitor 13b-K

This study investigates why the Omicron variant's main protease is less stable than the wild-type by analyzing its structure, enzymatic activity, and biophysical properties.

Rice OsPLATZ3 controls ROS homeostasis by inhibiting ROS-Scavenging Activity during Tapetum Degeneration

This study identifies OsPLATZ3 as a regulator of ROS homeostasis during tapetum degeneration in rice, showing its role in suppressing ROS scavenging and causing male sterility.

Phase Separation and Aggregation of α-Synuclein Diverge at Different Salt Conditions

This study investigates how salt concentration affects the phase separation and aggregation of alpha-synuclein, revealing distinct salt dependencies and dynamic transitions between assembly states.

Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer

This paper investigates how mispacking of the F87 sidechain in transthyretin tetramers affects conformational dynamics and aggregation propensity through structural and biophysical analyses.

Antagonistic Roles of Tau and MAP6 in Regulating Neuronal Development

The paper shows tau and MAP6 have opposing roles in neuronal development by regulating microtubule stability and dynamics in cultured neurons and in vivo.

Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.

Mathematical Modelling Indicates Th-cell Targeted Antibody-Dependent Cellular Cytotoxic Is a Crucial Obstacle Hurdling HIV Vaccine Development

This paper uses mathematical modeling to show that ADCC targeting Th cells hinders HIV vaccine development by damaging immune responses and reducing vaccine effectiveness.

Sounds of the underground reflect soil biodiversity dynamics across a grassy woodland restoration chronosequence

The paper uses ecoacoustics to measure soil biodiversity in a restoration chronosequence, finding higher acoustic complexity and diversity in revegetated and remnant plots compared to cleared plots.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

GTPase-activating protein ARAP1 regulates circular dorsal ruffles as a nutrient uptake mechanism in the Hep3B hepatocellular carcinoma cell line

This study shows that ARAP1 regulates circular dorsal ruffles in Hep3B cells, and its deletion reduces malignant potential, suggesting CDRs contribute to cancer development through nutrient uptake.

Potassium stimulates fruit sugar accumulation by increasing carbon flow in Citrus

This study shows potassium enhances sugar accumulation in citrus by boosting carbon flow between source and sink through phloem loading mechanisms.

Replacement of tibialis cranialis tendon with polyester, silicone-coated artificial tendon preserves biomechanical function in rabbits

This study evaluates an artificial tendon in rabbits, finding it preserves biomechanical function compared to tendon excision.