PKA disrupts adult ovarian identity circuits through direct inhibition of TRIM28-chromatin binding
Florian Chaleil, Lionel Le Gallic, Isabelle Sahut‐Barnola, Joris Mordier, Stéphanie Le Gras, Sylvain Roumeau, Céline Keime, Cyril Djari, Antoine Vigier, L. Badoil, Pierre Val, Jean‐Christophe Pointud, Constantine A. Stratakis, Florence M. Cammas, Antoine Martinez, , Anne‐Marie Lefrançois‐Martinez
This study shows PKA inhibits TRIM28-chromatin binding in ovarian granulosa cells, disrupting ovarian identity through SUMOylation dysregulation.
bioRxiv · Oct 7, 2026 · PreprintPhysiology