Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain
M. D. Gray, J. Feng, C. E. Weidle, K. W. Cohen, L. Ballweber-Fleming, A. J. MacCamy, C. N. Huynh, J. J. Trichka, D. Montefiori, G. Ferrari, M. Pancera, M. J. McElrath, L. Stamatatos
The paper identifies an antibody from a clinical trial that binds a different HIV-1 Env domain than VRC01-class antibodies and shows that epitope switching requires specific CDR changes.
bioRxiv · Aug 21, 2021Immunology