J. Feng

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide

This study shows that AOAH inactivates intestinal LPS, reducing MASLD by preventing hepatic lipid accumulation and altering lipid metabolism gene expression.

ClpP-dependent protein quality control supports antibiotic persistence in Campylobacter jejuni through bioenergetic homeostasis

This study identifies ClpP-dependent proteostasis as critical for antibiotic persistence in C. jejuni through bioenergetic homeostasis and metabolic remodeling.

Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids

This study identifies natural antibodies that enable Kupffer cells to capture and kill encapsulated bacteria in the liver, offering a potential therapeutic approach for septic bacterial diseases.

An effector XopL enhances ethylene biosynthesis to promote Xanthomonas fragariae infection in strawberry

This study identifies XopL as an effector that enhances ethylene biosynthesis in strawberry, promoting Xanthomonas fragariae infection by stabilizing FveACO9 and increasing ACO activity.

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

Role of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 in Maintaining Redox Homeostasis and DNA Repair in Non-Small Cell Lung Cancers Under EGFR-Targeting Therapy

This study shows that inhibiting PFKFB3 enhances the effectiveness of EGFR-TKIs by disrupting metabolic adaptations and DNA repair in drug-tolerant lung cancer cells.

A rapid and efficient in vivo inoculation method for introducing tree stem canker pathogens onto leaves: Suitable for large-scale assessment of resistance in poplar breeding progeny

This paper introduces an in vivo leaf inoculation method for assessing poplar resistance to V. sordida, showing it is more efficient and suitable for large-scale screening than traditional stem segment inoculation.

DNA-based ForceChrono Probes for Deciphering Single-Molecule Force Dynamics in Living Cells

This paper introduces DNA-based ForceChrono probes to measure single-molecule force dynamics in living cells, revealing precise loading rates and a link between force magnitude and duration.

Mating-compatibility genes employed as diagnostic markers to identify novel incursions of the myrtle rust pathogen Austropuccinia psidii

This study develops a diagnostic method using mating-type HD locus alleles to identify new incursions of the myrtle rust pathogen Austropuccinia psidii.

The Xanthomonas fragariae effector XopK suppresses stomatal immunity by perturbing abscisic acid signaling in strawberry

This study identifies XopK, an effector from Xanthomonas fragariae, which suppresses stomatal immunity by disrupting abscisic acid signaling in strawberries, leading to increased susceptibility to infection.

In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia

This study shows that cardiac dysfunction in septic shock occurs without high catecholamine levels or microvascular ischemia, and epinephrine infusions cause prolonged microvascular perfusion issues.

Cardiac Magnetic Resonance Studies in a Large Animal Model that Simulates the Cardiac Abnormalities of Human Septic Shock

This study uses cardiac magnetic resonance imaging in a canine sepsis model to show that ventricular wall edema and structural changes, not preload or afterload, explain differences in cardiac function and survival outcomes during sepsis.

Development of a qPCR assay and a LAMP assay for Verticillium longisporum detection and a triplex qPCR assay for simultaneous detection of V. longisporum, Leptosphaeria biglobosa and L. maculans from canola samples

A functional medicine and food homology composition discovery based on disease-related target and data mining against cardiac remodeling

This study identifies β-ecdysterone as a functional compound that counteracts cardiac remodeling by enhancing NRF2, revealing cross-talk between cardiac remodeling and neuromodulation.

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

This study identifies a novel human antibody, AF-03, that targets MARV glycoprotein and shows neutralizing activity against MARV and related filoviruses.

Distinct mechanisms by which antioxidant transcription factors Nrf1 and Nrf2 as drug targets contribute to the anticancer efficacy of Cisplatin on hepatoma cells

This study investigates how antioxidant transcription factors Nrf1 and Nrf2 influence the anticancer effect of Cisplatin on hepatoma cells through distinct molecular mechanisms.

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

Efficacy of the oral nucleoside prodrug GS-5245 (Obeldesivir) against SARS-CoV-2 and coronaviruses with pandemic potential

This study evaluates the antiviral efficacy of GS-5245 against multiple SARS-CoV-2 variants and other coronaviruses, showing broad in vitro activity and protective effects in animal models.

Immuno-Engineered Mitochondria for Efficient Therapy of Acute Organ Injuries via Modulation of Inflammation and Cell Repair

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

METTL16 Controls Kaposi's Sarcoma-Associated Herpesvirus Replication by Regulating S-Adenosylmethionine Cycle

This study shows METTL16 suppresses KSHV lytic replication by regulating the SAM cycle and redox homeostasis.

Integrin beta4 promotes DNA damage drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/Rac1

This study identifies the Integrin β4/TNFAIP2/IQGAP1/RAC1 pathway as a mechanism for DNA damage drug resistance in triple-negative breast cancer.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

Detection and differentiation of Xanthomonas translucens pathovars translucens and undulosa from wheat and barley by duplex quantitative PCR

This paper develops two duplex qPCR systems to specifically detect and differentiate Xanthomonas translucens pathovars translucens and undulosa in wheat and barley.

Gaudichaudione H inhibits Herpes Simplex Virus-1 replication by regulating cellular nuclear factor-κB in an interferon-γ-independent manner

This paper identifies Gaudichaudione H as an antiviral compound that inhibits HSV-1 replication by suppressing NF-κB activation without requiring interferon-γ.

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancer

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

Inhibiting POLQ-mediated alternative NHEJ enhances CRISPR/Cas9 mediated precise genome editing in CHO cells

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

N6-methyladenosine (m6A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infections

The paper shows that m6A and YTHDF2 regulate DUSP1 to enhance innate immune response during infections by promoting DUSP1 degradation and activating MAPKs.

CRISPR/FnCas12a-mediated efficient multiplex and iterative genome editing in bacterial plant pathogens without donor DNA templates

This paper develops a CRISPR/Cas12a-based genome editing method for bacterial plant pathogens without donor DNA, enabling efficient gene knockout and multiplex editing in Xanthomonas oryzae pv. oryzae.

Mechanical force induces DRP1-dependent asymmetrical mitochondrial fission for quality control

The paper shows mechanical force induces DRP1-dependent asymmetrical mitochondrial fission, leading to mtDNA-free fragments that recruit Parkin proteins.

Atomistic Insights Into The Mechanism of Dual Affinity Switching In Plant Nitrate Transporter NRT1.1

The paper uses simulations to explain how phosphorylation regulates dual-affinity switching in the plant nitrate transporter NRT1.1 by stabilizing transport states and decoupling dimer dynamics.