The chikungunya virus E1 glycoprotein fusion loop and hinge alter glycoprotein dynamics leading to cell and host specific changes in infectivity.
S. A. Thannickal, L. Battini, S. N. Spector, M. G. Noval, D. E. Alvarez, K. A. Stapleford
This study investigates how mutations in the CHIKV E1 glycoprotein's fusion loop and hinge affect virus infectivity in different cell types and hosts by altering E1-E2 dynamics.
bioRxiv · Nov 3, 2023 · PreprintMicrobiology