K. A. Stapleford

This study shows SARS-CoV-2 infects macrophages in coronary atherosclerotic lesions, causing inflammation that may increase cardiovascular risk.

This study investigates the role of the La Crosse virus (LACV) class II fusion glycoprotein ij loop in infectivity and cholesterol-dependent entry, showing that specific residues are critical for virus function.

This study investigates CHIKV-induced heart disease using mouse models and human cells, showing MAVS signaling is critical for viral clearance and preventing chronic vascular inflammation.

This study identifies structurally conserved domains in flavivirus and alphavirus fusion glycoproteins that contribute to replication and infectious virion production, suggesting potential targets for broad-spectrum antivirals.

This paper identifies emerging chikungunya virus E1 glycoprotein variants that enhance virus attachment, alter antibody neutralization, and increase inflammation in mice.

This paper introduces a 2D-MBBA assay for SARS-CoV-2 serology profiling and uses machine learning to predict neutralization capacity from antibody profiles.

This study examines inter-individual variability in SARS-CoV-2 infection of intestinal organoids, finding that ACE2 expression levels determine susceptibility and that Omicron variant shows higher infectivity.

The paper shows that gut microbiome dysbiosis in COVID-19 patients is linked to increased risk of bacteremia and microbial translocation.

This study establishes a ZIKV transmission model in immunocompromised mice to investigate factors influencing viral evolution and DVG production.

The paper describes a modified soluble ACE2 protein that effectively inhibits SARS-CoV-2 infection in cell culture with higher potency than previous versions.

The paper assesses neutralization capacity and antibody titers against SARS-CoV-2 antigens in recovered healthcare workers, finding that high titers of multiple isotypes correlate with neutralization.

The paper identifies key glycoprotein residues in alphaviruses that regulate infectivity and dissemination through evolutionary analysis and functional studies.