Author

L. Baxt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. J. Huggins· 2 shared J. Ginn· 2 shared N. Liverton· 2 shared R. Liang· 2 shared A. J. Hudspeth· 1 shared A. Nagiel· 1 shared A. W. Stamford· 1 shared D. Tomita· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

D. J. Huggins

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2 papers

Recent·Most cited

Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs

N. R. Kastan, S. Oak, R. Liang, L. Baxt, R. W. Myers, J. Ginn, N. Liverton, D. J. Huggins, J. Pichardo, M. Paul, T. S. Carroll, A. Nagiel, K. Gnedeva, A. J. Hudspeth

This paper describes the development of a more potent Lats kinase inhibitor, TDI-011536, which promotes cell proliferation and regeneration in mammalian tissues.

bioRxiv · Apr 7, 2022Cell Biology

A chemical strategy toward novel brain-penetrant EZH2 inhibitors

R. Liang, D. Tomita, Y. Sasaki, J. Ginn, M. Michino, D. J. Huggins, L. Baxt, S. Kargman, M. Shahid, K. Aso, M. Duggan, A. W. Stamford, E. DeStanchina, N. Liverton, P. T. Meinke, , R. E. Phillips

This paper identifies a chemical strategy to develop brain-penetrant EZH2 inhibitors and reports two novel compounds with improved properties.

bioRxiv · Jun 10, 2021Cancer Biology