Conformational diversity in class C GPCR positive allosteric modulation
G. Cannone, L. Berto, F. Malhaire, G. Ferguson, A. Fouillen, S. Balor, J. Font-Ingles, A. Llebaria, C. GOUDET, A. Kotecha, V. R. Kutti, G. Lebon
This study reports cryoEM structures of mGlu5 receptor with different PAMs, showing how PAM binding modulates receptor conformation and function.
bioRxiv · Nov 7, 2023Biochemistry