Author

L. de Jong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

W. Roseboom· 3 shared G. Kramer· 2 shared A. H. Friggen· 1 shared A. M. oliveira paiva· 1 shared C. G. de Koster· 1 shared E. A. de Koning· 1 shared G. L. Corthals· 1 shared H. Buncherd· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiochemistry

W. Roseboom

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Author profile →

4 papers

Recent·Most cited

Cross-link scrambling in peptide pairs

L. de Jong, G. Kramer, W. Roseboom

The paper identifies cross-link types in peptides using SCXC retention time prediction and shows that MS/MS analysis reveals ester linkages in some amide-predicted pairs due to gas-phase rearrangement.

bioRxiv · Dec 27, 2022 · PreprintBiochemistry

A composite filter for low FDR of protein-protein interactions detected by in vivo cross-linking

L. de Jong, W. Roseboom, G. Kramer

The paper introduces a composite filter to reduce the false discovery rate of protein-protein interactions detected by in vivo cross-linking using BAMG and pLink 2.

bioRxiv · May 15, 2020Biochemistry

The C-terminal domain of Clostridioides difficile TcdC is exposed on the bacterial cell surface

A. M. oliveira paiva, L. de Jong, A. H. Friggen, W. K. Smits, J. Corver

This study shows the C-terminal domain of TcdC in C. difficile is extracellular, challenging its proposed role as an anti-sigma factor.

bioRxiv · Dec 11, 2019Microbiology

In culture cross-linking of bacterial cells reveals proteome scale dynamic protein-protein interactions at the peptide level

L. de Jong, E. A. de Koning, W. Roseboom, H. Buncherd, M. J. Wanner, P. J. Jansen, I. Dapic, J. H. van Maarseveen, G. L. Corthals, P. J. Lewis, L. W. Hamoen, C. G. de Koster

The paper develops a method to identify dynamic protein-protein interactions at the peptide level in bacteria using cross-linking in culture, revealing new interactions in transcription and translation.

Journal of Proteome Research · Jul 7, 2017Peer-reviewedBiochemistry