Author

L. Doretto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:zebrafish· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. S. Rodrigues· 3 shared R. H. Nobrega· 3 shared A. Tovo-Neto· 2 shared J. M. B. Ricci· 2 shared A. J. Butzge· 1 shared B. Marques· 1 shared C. Shao· 1 shared D. Costa· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCell Biology

M. S. Rodrigues

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3 papers

Recent·Most cited

TGF-β and BMP subfamily pathways in zebrafish spermatogonial niche: A83-01 and DMH1 inhibitor effects in spermatogonial self-renewal and differentiation

D. F. Costa, J. M. B. Ricci, M. S. Rodrigues, M. A. Oliveira, L. Doretto, R. H. Nobrega

This study investigates the roles of TGF-β and BMP subfamily pathways in zebrafish spermatogonial self-renewal and differentiation using inhibitors A83-01 and DMH1, showing antagonistic effects on spermatogonia fate.

bioRxiv · Oct 21, 2022 · PreprintCell Biology

Thyroid hormones deficiency impairs male germ cell development: a cross talk between hypothalamic-pituitary-thyroid, and - gonadal axes in zebrafish

M. S. Rodrigues, A. Tovo-Neto, I. F. da Rosa, L. Doretto, H. Pourmohammad, H. Habibi, R. H. Nobrega

This study shows that thyroid hormone deficiency impairs male germ cell development in zebrafish by disrupting spermatogenesis and testicular function.

bioRxiv · Jan 30, 2022Cell Biology

Gdnf, a germ cell-derived factor, regulates zebrafish germ cell stemness through the creation of new spermatogonial niches (germ and Sertoli cells) and inhibition of spermatogonial differentiation in an autocrine and paracrine manners

L. Doretto, A. J. Butzge, R. T. Nakajima, E. R. M. Martinez, B. Marques, M. S. Rodrigues, I. F. Rosa, J. M. B. Ricci, A. Tovo-Neto, D. Costa, G. Malafaia, C. Shao, R. H. Nobrega

This study shows Gdnf maintains zebrafish germ cell stemness by creating new niches and inhibiting differentiation through autocrine and paracrine mechanisms.

bioRxiv · Dec 25, 2021 · PreprintCell Biology