Mechanistic insights into the activation of lecithin-cholesterol acyltransferase in therapeutic nanodiscs composed of apolipoprotein A-I mimetic peptides and phospholipids
L. Giorgi, A. Niemela, E.-P. Kumpula, O. Natri, P. Parkkila, J. T. Huiskonen, A. S. Koivuniemi
This study investigates how apoA-I mimetic peptides modulate LCAT activity in nanodiscs through molecular dynamics simulations and experiments, revealing structural and functional insights.
bioRxiv · Jun 9, 2022Biophysics