Structural insights into the cooperative interaction of the intrinsically disordered co-activator TIF2 with retinoic acid receptor heterodimer (RXR/RAR)
L. Senicourt, A. le Maire, F. Allemand, J. E. Carvalho, L. Guee, P. Germain, M. Schubert, P. Bernado, W. Bourguet, N. Sibille
The paper determines the structural features of TIF2NRID and its cooperative binding to RXR/RAR, revealing partially structured regions and the role of flanking sequences.
bioRxiv · Oct 28, 2020Biophysics