M. Schubert

Drought tolerance as an evolutionary precursor to frost and winter tolerance in grasses

The paper investigates whether drought tolerance preceded frost and winter tolerance in grasses, finding mixed evolutionary trajectories and supporting ancestral drought tolerance as a facilitator for cold biome transitions in some clades.

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy

This study shows that aneuploid cancer cells adapt by reducing chromosomal instability and inflammation, with KRAS amplification aiding this adaptation.

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

African bush pigs exhibit porous species boundaries and appeared in Madagascar concurrently with human arrival

This study analyzes whole genomes of African bushpigs and Malagasy bushpigs, revealing recent divergence and gene flow, challenging species boundaries and linking their arrival in Madagascar to human migration.

Predicting CIN rates from single-cell whole genome sequencing data using an in silico model

The paper develops an in silico model, CINsim, to predict chromosomal instability (CIN) rates from single-cell whole genome sequencing data by simulating karyotype dynamics and validating it in mouse and human cancer models.

Persistent gene flow suggests an absence of reproductive isolation in an African antelope speciation model

The paper sequenced waterbuck genomes to study speciation, finding historical gene flow across a Rift Valley barrier and no reproductive isolation.

MND1 enables repair of two-ended DNA double-strand breaks

This study shows MND1 facilitates repair of two-ended DNA double-strand breaks in somatic cells through homologous recombination, but not one-ended breaks, and its absence increases IR-induced toxicity.

Short-term molecular consequences of chromosome mis-segregation for genome stability

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

Immunity to SARS-CoV-2 up to 15 months after infection

This study tracks SARS-CoV-2 immunity in patients up to 15 months post-infection, showing sustained antibody and memory B/T cell responses but reduced neutralization against variants.

Monosomies, trisomies and segmental aneuploidies differentially affect chromosomal stability

This study investigates how different aneuploidies affect chromosomal instability in human cells, finding that trisomies increase segregation errors while monosomies do not induce CIN.

Effects of Hydroxychloroquine and Azithromycin on iPSC-derived Cardiomyocytes: Considerations for the Treatment of COVID-19 Patients

This study investigates the effects of HCQ and AZM on iPSC-derived cardiomyocytes, finding that their combination significantly increases cardiotoxicity and electrophysiological dysfunction.

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to most known recently emerging RBD mutations

The paper describes the selection of a SARS-CoV-2 neutralizing antibody from COVID-19 patients using phage display, showing it binds the ACE2-RBD interface and remains effective against emerging RBD mutations.

Persistence of SARS-CoV-2 specific B- and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection

This study tracks SARS-CoV-2 specific B- and T-cell responses in convalescent patients 6-8 months post-infection, finding sustained memory cell responses despite declining antibody levels.

Structural insights into the cooperative interaction of the intrinsically disordered co-activator TIF2 with retinoic acid receptor heterodimer (RXR/RAR)

The paper determines the structural features of TIF2NRID and its cooperative binding to RXR/RAR, revealing partially structured regions and the role of flanking sequences.

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

The paper identifies potent SARS-CoV-2 neutralizing antibodies from pre-pandemic human donors that bind the RBD-ACE2 interface, showing high neutralization efficacy in vitro.

Gain of gene regulatory network interconnectivity at the origin of vertebrates

The paper shows that increased interconnectivity between signaling pathways and gene regulatory networks contributed to vertebrate evolution by enabling new gene expression patterns and cell types.

CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor

This paper combines CIS checkpoint deletion with CAR engineering in NK cells to enhance their metabolic fitness and anti-tumor activity in a lymphoma model.

Altering microtubule dynamics is synergistically toxic with inhibition of the spindle checkpoint

The paper identifies synergistic toxicity between microtubule dynamics alteration and SAC inhibition in aneuploid cells.

Monitoring contractility in single cardiomyocytes and whole hearts with bio-integrated microlasers

This paper introduces microlasers to monitor cardiac contractility in single cells and whole hearts, revealing sarcomeric protein density changes as a key factor in contraction.

The grass subfamily Pooideae: late Cretaceous origin and climate-driven Cenozoic diversification

This study estimates the origin and diversification of the grass subfamily Pooideae, finding a late Cretaceous origin and climate-driven diversification during the Cenozoic.

Evolution of cold acclimation in temperate grasses (Pooideae)

This study investigates cold acclimation in early diverging Pooideae lineages and finds that while cold acclimation exists, regulatory genes are not conserved and show lineage-specific evolution.