Spatially discrete signalling niches regulate fibroblast heterogeneity in human lung cancer
C. J. Hanley, S. Waise, R. Parker, M. A. Lopez, J. Taylor, L. Kimbley, J. West, C. H. Ottensmeier, M. J. Rose-Zerilli, G. J. Thomas
The paper identifies fibroblast subpopulations in lung cancer using single-cell RNA sequencing and shows their spatial distribution and regulation by TGF-β1 and IL-1.
bioRxiv · Jun 8, 2020 · PreprintCancer Biology