RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion
T. Radaszkiewicz, M. Noskova, K. Gömöryova, O. Vondalova Blanarova, K. A. Radaszkiewicz, M. Pickova, R. Vichova, T. Gybel, K. Kaiser, L. Demkova, L. Kucerova, D. Potesil, Z. Zdrahal, K. Soucek, V. Bryja
This study shows RNF43 inhibits WNT5A signaling and suppresses melanoma invasion by ubiquitinating VANGL2 and internalizing ROR1, leading to worse prognosis in RNF43-low patients.
bioRxiv · Feb 8, 2021Cancer Biology