Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats
L. Lindenburg, T. Pantelejevs, F. Gielen, P. Zuazua-Villar, M. Butz, E. J. Rees, C. F. Kaminski, J. Downs, M. Hyvonen, F. Hollfelder
The paper creates and tests chimeric BRC repeats to improve RAD51 binding, finding that shuffled modules can enhance binding affinity and function in human cells.
bioRxiv · May 14, 2020Biochemistry