M. Hyvonen

This paper describes a recombinant approach for stapled peptide discovery and evaluates its effectiveness as inhibitors of the RAD51 recombinase.

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

This study identifies a novel β-glucuronidase from a metagenomic library using microfluidic droplet screening, revealing a new GH3 family member with unique functional and structural properties.

The paper investigates the binding of two BRC repeats from Leishmania infantum BRCA2 to RAD51, revealing distinct binding modes and affinities compared to human BRC4.

This study investigates the mechanical properties of consensus-designed tetratricopeptide repeats (CTPRs) using single-molecule techniques, revealing their spring-like behavior and superhelical structure.

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

The paper creates and tests chimeric BRC repeats to improve RAD51 binding, finding that shuffled modules can enhance binding affinity and function in human cells.

The paper characterizes the RALF gene family in strawberry species, identifying genomic structure and transcriptional regulation during host-pathogen interactions.

This study characterizes the latent and activated states of GDF8 using structural and mutagenesis analyses, revealing that latent GDF8 is spring-loaded and can be activated without proteolytic cleavage.

This study determines the structure of human pro-myostatin and identifies features responsible for its latent state, offering insights into myostatin activation and potential inhibitor design.