Preadaptation of pandemic GII.4 noroviruses in hidden virus reservoirs years before emergence
C. Ruis, L. Lindesmith, M. Mallory, P. D. Brewer-Jensen, J. Bryant, V. Costantini, C. Monit, J. Vinje, R. S. Baric, R. A. Goldstein, J. A. Breuer
This paper shows that GII.4 noroviruses preadapt and circulate undetected for years before causing a new pandemic, with changes in host immunity enabling spread rather than genetic changes alone.
bioRxiv · Jun 3, 2019Evolutionary Biology