Evolutionary BiologybioRxiv
Preadaptation of pandemic GII.4 noroviruses in hidden virus reservoirs years before emergence
C. Ruis, L. Lindesmith, M. Mallory…·J. A. Breuer
This paper shows that GII.4 noroviruses preadapt and circulate undetected for years before causing a new pandemic, with changes in host immunity enabling spread rather than genetic changes alone.
DOI 10.1093/ve/veaa067