Full-length native CGRP neuropeptide and its stable analogue SAX, but not CGRP peptide fragments, inhibit mucosal HIV-1 transmission
M. Bomsel, A. Sams, E. Cohen, A. Sennepin, G. Siracusano, F. Sanvito, L. Edvinsson, L. Lopalco, Y. Ganor
The paper shows that full-length CGRP and its analogue SAX inhibit HIV-1 transmission via Langerhans cells, while fragments do not, and CGRP enters mucosal tissues without altering immune cell distribution.
bioRxiv · Mar 8, 2021 · PreprintMicrobiology