M. Bomsel

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

This paper shows that MK-8722, a direct AMPK activator, inhibits SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy, and enhancing type I IFN response, even when applied post-exposure.

CGRP inhibits SARS-CoV-2 infection of bronchial epithelial cells and its pulmonary levels correlate with viral clearance in critical COVID-19 patients

Full-length native CGRP neuropeptide and its stable analogue SAX, but not CGRP peptide fragments, inhibit mucosal HIV-1 transmission

The paper shows that full-length CGRP and its analogue SAX inhibit HIV-1 transmission via Langerhans cells, while fragments do not, and CGRP enters mucosal tissues without altering immune cell distribution.

Capsaicin activates TRPV1 in human Langerhans cells and inhibits mucosal HIV-1 transmission via secreted CGRP

This study shows that TRPV1 activation in Langerhans cells increases CGRP secretion, which inhibits HIV-1 trans-infection, suggesting TRPV1 agonists could be used as topical microbicides.

IL-7-adjuvanted vaginal vaccine elicits strong mucosal immune responses in non-human primates

This study shows that IL-7-adjuvanted vaginal vaccination in macaques enhances mucosal immune responses by promoting chemokine expression, immune cell infiltration, and tertiary lymphoid structure formation.