Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands
A. L. Nichols, Z. Blumenfeld, C. Fan, L. Luebbert, A. E. M. Blom, B. N. Cohen, J. S. Marvin, P. M. Borden, C. H. Kim, A. K. Muthusamy, A. V. Shivange, H. J. Knox, H. R. Campello, J. H. Wang, D. A. Dougherty, , H. A. Lester
The paper develops new fluorescent sensors to study the pharmacokinetics of nicotinic partial agonists in living cells and identifies differences in membrane crossing rates among these drugs.
bioRxiv · Oct 4, 2021Pharmacology & Toxicology