C. Fan

Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

This study shows that artesunate, EDTA, and colistin work together to fight Salmonella strains resistant to colistin, by damaging cell membranes and inhibiting MCR-1.

Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel

This study investigates how psychostimulant derivatives modulate the prokaryotic pentameric ligand-gated ion channel sTeLIC through a vestibular pocket, revealing a structure-function mechanism for allosteric potentiation.

Generative Adversarial Networks Accurately Reconstruct Pan-Cancer Histology from Pathologic, Genomic, and Radiographic Latent Features

This paper introduces HistoXGAN, a GAN that reconstructs cancer histology from latent features, showing it retains tumor grade, histologic subtype, and gene expression patterns across 29 cancer types.

ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses

The paper identifies ACE2 as a receptor for HKU5 coronaviruses from Pipistrellus abramus bats and investigates receptor tropism across merbecovirus clades.

Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

Divergent mechanisms of steroid inhibition in the human {rho}1 GABA(A) receptor

The paper characterizes the inhibitory mechanisms of two neuroactive steroids at the human {rho}1 GABAA receptor using cryo-EM, electrophysiology, and molecular dynamics simulations.

Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

Zotatifin targets EIF4A to suppress TNBC by inhibiting Sox4, inducing interferon response, and reprogramming the tumor immune microenvironment, synergizing with chemotherapy.

Structure and dynamics of differential ligand binding in the human {rho}-type GABA(A) receptor

This study presents cryo-EM structures of the human ρ1 GABAAR under different conditions, revealing structural mechanisms of gating and modulation with implications for pharmaceutical design.

IL-15 priming alters IFN-γ regulation in murine NK cells

This study shows that IL-15 priming changes IFN-γ regulation in murine NK cells by altering transcriptional responses to activating receptor stimulation.

Repurposing the Memory-promoting Meclofenoxate Hydrochloride as a Treatment for Parkinson's Disease through Integrative Multi-omics analysis

This study identifies meclofenoxate hydrochloride as a potential treatment for Parkinson's disease by improving mitochondrial metabolism and brain function through multi-omics analysis and experimental validation.

Mre11 liberates cGAS from nucleosome sequestration during tumorigenesis

Mre11 facilitates cGAS activation by displacing it from nucleosome sequestration, promoting ZBP1-dependent necroptosis and suppressing tumor growth.

Structure of an endogenous mycobacterial MCE lipid transporter

The paper reports the cryo-EM structure of the Mce1 fatty acid import machine from Mycobacterium smegmatis, revealing its assembly and a previously unknown subunit, LucB.

Formation process of the twinning β-form anhydrous guanine platelets in the scallop eyes

This study reports the formation mechanism of twinning β-form anhydrous guanine microplatelets in scallop eyes, revealing an intermediate amorphous phase and a two-step crystallization process.

Programming super DNA-enzyme molecules for on-demand enzyme activity modulation

This paper develops a super DNA-enzyme molecule (SDEM) that enables on-demand enzyme activity modulation with improved detection limits and reaction rates compared to free enzymes.

Macrophage migrates on alternate non-adhesive surfaces

This study shows macrophages can migrate across non-adhesive PEG surfaces by adopting a mesenchymal mode, overcoming the limitations seen in other cell types.

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes

This study identifies cross-reactive monoclonal antibodies against conserved sarbecovirus epitopes using mosaic RBD nanoparticles and shows their neutralization potential against SARS-CoV-2 variants and animal sarbecoviruses.

Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models

This study designs mosaic RBD nanoparticles to elicit antibodies against conserved sarbecovirus epitopes, showing broader protection against SARS-CoV-2 variants and animal sarbecoviruses in animal models.

CXCR2 inhibition enables NASH-HCC immunotherapy

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

High-performance Saccharomyces cerevisiae-based biosensor for heavy metal detection

This paper develops a Saccharomyces cerevisiae-based biosensor for copper ion detection with reduced noise and improved signal output, using colorimetric and olfactory outputs for on-site monitoring.

Glutathione binding to the plant At Atm3 transporter and implications for the conformational coupling of ABC transporters

The paper determines structures of AtAtm3 in multiple conformational states and examines glutathione binding and its implications for ABC transporter function.

A live attenuated influenza virus-vectored intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2 infection

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands

The paper develops new fluorescent sensors to study the pharmacokinetics of nicotinic partial agonists in living cells and identifies differences in membrane crossing rates among these drugs.

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics

This study develops and characterizes patient-derived TNBC organoids that recapitulate tumor properties and identify key signaling pathways involved in cancer progression.

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

ZHX2 Promotes HIF1α Oncogenic Signaling in Triple-Negative Breast Cancer

This study identifies ZHX2 as a promoter of HIF1α oncogenic signaling in TNBC, showing its role in cell growth, invasion, and metastasis through interaction with HIF1.

Species-specific gene duplication in Arabidopsis thaliana evolved novel phenotypic effects on morphological traits under strong positive selection

This study identifies a young gene in Arabidopsis thaliana that shows strong positive selection and contributes to morphological trait divergence through neofunctionalization.

Tissue-specific accumulation profiles of phorbol esters in Jatropha curcas and gene induction in response to abiotic and biotic stresses

The paper analyzes phorbol ester distribution in Jatropha curcas tissues and links it to gene expression under various stresses.

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

A soluble ACE2 microbody protein fused to a single immunoglobulin Fc domain is a potent inhibitor of SARS-CoV-2 infection in cell culture

The paper describes a modified soluble ACE2 protein that effectively inhibits SARS-CoV-2 infection in cell culture with higher potency than previous versions.

SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.