Immunotherapy efficacy in colorectal cancer is dependent on activation of a microbial-metabolite-immune circuit
L. Mager, R. Burkhard, N. Cooke, K. Brown, H. Ramay, S. Paik, J. Stagg, R. Grooves, M. Gallo, I. Lewis, M. Geuking, K. McCoy
This study identifies specific gut bacteria and the metabolite inosine that enhance immunotherapy efficacy in colorectal cancer by promoting Th1 cell activation through the adenosine A2A receptor.
bioRxiv · Feb 26, 2020 · PreprintCancer Biology