M. Gallo

Single cell spatial analysis identifies regulators of brain tumor initiating cells

The paper identifies biglycan as a regulator of brain tumor initiating cells through spatial transcriptomics and single-cell ATAC-seq, showing its role in Wnt/β-catenin pathway activation and tumor growth.

Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila

The paper identifies FOXO-dependent gene expression changes in Drosophila under hypoxia, revealing Hipk as a key regulator of hypoxia survival and uncovering FOXO's role in suppressing energy-intensive processes.

Shedding Light on the Black Box of a Neural Network Used to Detect Prostate Cancer in Whole Slide Images by Occlusion-Based Explainability

This paper presents a deep learning system for prostate cancer detection in whole slide images and uses occlusion-based explainability to identify key histomorphological features used for classification.

Gut microbe Lactiplantiballus plantarum undergoes different evolutionary trajectories between insects and mammals

This study tracks the evolutionary trajectories of Lactiplantibacillus plantarum in Drosophila and mammalian hosts, finding diet-driven evolution in insects and host-intrinsic factors driving divergence in mammals.

Beneficial Lactiplantibacillus plantarum promote Drosophila growth by down-regulating the expression of PGRP-SC1

This study identifies PGRP-SC1 down-regulation by beneficial Lactiplantibacillus plantarum as a mechanism promoting Drosophila growth through increased microbial proliferation and metabolite production.

macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network

This study identifies macroH2A2 as a regulator of chromatin accessibility at enhancers in glioblastoma, showing that inhibiting Menin increases macroH2A2 and represses self-renewal.

Extracellular signal-regulated kinase mediates chromatin rewiring and lineage transformation in lung cancer

This study identifies the ERK-CBP/p300-ETS axis as promoting lineage transformation between neuroendocrine and non-neuroendocrine lung cancer subtypes through chromatin rewiring.

Characterization and variation of bacterial and fungal communities from the sapwood of Apulian olive varieties with different susceptibility to Xylella fastidiosa

The paper studies cultivable endophytes in Apulian olive sapwood, showing seasonal and geographical variation and identifying potential biocontrol agents against Xylella fastidiosa.

CASCADES, a novel SOX2 super-enhancer associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma multiforme

This study identifies CASCADES, a lncRNA that regulates stemness in glioblastoma cancer stem cells by epigenetically controlling SOX2 expression.

Gain-of-function mutations amplify cytotoxic FAM111 protease activity in human genetic disorders

The paper shows that gain-of-function mutations in FAM111A and FAM111B enhance protease activity, leading to DNA replication and transcription suppression and cell death, contributing to genetic disorders.

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.

Immunotherapy efficacy in colorectal cancer is dependent on activation of a microbial-metabolite-immune circuit

This study identifies specific gut bacteria and the metabolite inosine that enhance immunotherapy efficacy in colorectal cancer by promoting Th1 cell activation through the adenosine A2A receptor.

High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma

This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.

Subclonal architecture, evolutionary trajectories and patterns of inheritance of germline variants in pediatric glioblastoma

This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.

New genes and functional innovation in mammals

The paper identifies mammalian-specific gene families and finds that new genes often originate from non-coding regions and are expressed in testis, suggesting a role for sexual selection in their evolution.