Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized 13C magnetic resonance spectroscopy
L. M. Le Page, O. J. Rider, A. J. Lewis, V. Noden, M. Kerr, L. Giles, L. J. A. Ambrose, V. Ball, L. Mansor, L. C. Heather, D. J. Tyler
This study uses hyperpolarized 13C MRS to assess cardiac metabolism under acute and chronic hypoxia in rats, finding altered PDH flux and lactate conversion after 30 minutes and one week of hypoxia.
bioRxiv · Dec 13, 2018Physiology