The paracaspase MALT1 controls cholesterol homeostasis in glioblastoma stem-like cells through lysosome proteome shaping
C. Maghe, K. Trillet, G. A. Gregoire, M. Kerherve, L. Merlet, K. A. Jacobs, N. Bidere, J. Gavard
This study shows that MALT1 regulates cholesterol homeostasis in glioblastoma stem-like cells by shaping the lysosome proteome, leading to cell death when disrupted.
bioRxiv · Feb 27, 2023Cancer Biology