Author

L. Moparthi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:electrophysiology· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. M. Zygmunt· 3 shared S. Koch· 2 shared G. Pizzolato· 1 shared J. Wenger· 1 shared M. Filipovic· 1 shared S. B. Moparthi· 1 shared V. Sinica· 1 shared V. Vlachova· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 10 mutual co-author links

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3 shared papersPhysiology

P. M. Zygmunt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

FOX transcription factors are common regulators of Wnt/β-catenin signaling

L. Moparthi, S. Koch

This study systematically investigates the role of FOX transcription factors in Wnt/β-catenin signaling, identifying their regulatory contributions and classifying them as positive or negative regulators.

bioRxiv · Dec 13, 2022 · PreprintCell Biology

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

L. Moparthi, V. Sinica, M. Filipovic, V. Vlachova, P. M. Zygmunt

This paper investigates the temperature sensitivity of hTRPA1 by analyzing truncated proteins, finding that cold and heat sensitivity involve distinct structural changes in the C-terminal domain.

bioRxiv · Jul 31, 2021Physiology

Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin

L. Moparthi, S. B. Moparthi, J. Wenger, P. M. Zygmunt

bioRxiv · Mar 19, 2020Physiology

Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel

P. M. Zygmunt, L. Moparthi

This study shows that human TRPA1 is a mechanosensitive ion channel gated by bilayer pressure, with responses modulated by redox state.

bioRxiv · Mar 5, 2020Physiology

Wnt activator FOXB2 drives prostate cancer neuroendocrine differentiation

L. Moparthi, G. Pizzolato, S. Koch

This study identifies FOXB2 as a Wnt activator that drives neuroendocrine differentiation in prostate cancer and is associated with poor recurrence-free survival.

bioRxiv · Mar 3, 2019Cancer Biology