The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain
L. Moparthi, V. Sinica, M. Filipovic, V. Vlachova, P. M. Zygmunt
This paper investigates the temperature sensitivity of hTRPA1 by analyzing truncated proteins, finding that cold and heat sensitivity involve distinct structural changes in the C-terminal domain.
bioRxiv · Jul 31, 2021Physiology